Collagenase production by rheumatoid synovial cells: stimulation by a human lymphocyte factor.
نویسندگان
چکیده
Human peripheral blood lymphocytes incubated in culture for 1 to 3 days at 37 degree C, but not at 4 degree C, release a soluble factor which can stimulate, up to 400-fold, collagenase production by isolated, adherent, rheumatoid synovial cells. Production of lymphocyte factor is enhanced by phytohemagglutinin or concanavalin A. By gel filtration the factor has an apparent molecular weight of about 12,000.
منابع مشابه
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ورودعنوان ژورنال:
- Science
دوره 195 4274 شماره
صفحات -
تاریخ انتشار 1977